Join Christopher Lipinski and Barry Bunin for a discussion on the "Lipinski Rules of 5," which has become the benchmark by which almost all drug discovery analyses are now compared.

Register here: https://info.collaborativedrug.com/lipinski-bunin-ruleof5-0-0

​Experts will discuss:

• Advanced drug discovery & data screening methods
• What is the Lipinski Rule of 5 & How you can go beyond the Rule of 5 to achieve better results
• New technologies to better assess the quality of your screening data
• Experimental culture and sociology as a factor in clustering your results
• How scientists can (and should) respond to the growing opioid addiction crisis – which has actually lowered life expectancy in America

EndNote provides a number of terms list to make sure that the journal names in your bibliography are either the full name or abbreviation as your style requires. To set up your terms list, first make a backup of your library as described here. Then, please follow the steps below. The procedure is also shown in an embedded video following the steps.  

1. In EndNote, go to "Tools > Open Term Lists > Journal Terms List". 
2. Highlight the first journal, and press [Ctrl]+A on the keyboard to highlight all the terms (on a Macintosh, this would be [Command]+A). Note: If the Journal Terms List is empty, skip to step 4.
3. Next, press the "Delete Term" button to the right to empty the list of old terms.
4. Go to the "Lists" tab at the top, and click on the "Import List" button.
5. Browse to the Term Lists folder within the EndNote folder, and choose to open the Medical text file (assuming you want to use the Index Medicus abbreviations). 
   
   If you are on a Windows machine, this folder should default to:
   C:\Program Files\EndNote (EndNote Version Number)\Terms Lists
   
   If you are on a 64-bit Windows machine, this folder should default to:
   C:\Program Files (X86)\EndNote (EndNote Version Number)\Terms Lists
   
   If you are on a Mac, this folder should default to:
   Hard Drive: Applications: EndNote (EndNote Version Number): Terms 
6. This will import the correct abbreviations into your library's term list.
7. Next, to make sure the style is using the correct substitution, go to "Edit > Output Styles > Open Style Manager".
8. In the list of styles, highlight the style you are using and click the "Edit" button.
9. Click on "Journal Names" on the left.

If Endnote changes the words of the title to lowercase:

You can add terms to an exclusion list so that EndNote does not change the case of the added terms.
In EndNote, go to: EndnoteX7 -> Preferences.
Click on the first option 'Change Case'.
Enter the terms one by one and click on 'Add'
After entering all terms you can click on 'OK' or 'Apply'.


Source

Reviews published in Chemical Reviews are state of the art and a must-read for all scientists in the Natural Sciences. 

We 've chosen the following most recent thematic issues as most relevant to drug design and drug delivery design.

Physical Chemistry

Water - The Most Anomalous Liquid
July 13, 2016 (Volume 116, Issue 13, pp. 7459-7726)
Editorial | Table of Contents

Noncovalent Interactions
May 11, 2016 (Volume 116, Issue 9, pp. 4911-5688)
Editorial | Table of Contents

Nanomaterials

Nanoparticle Chemistry
September 28, 2016 (Volume 116, Issue 18, pp. 10343-11290)
Editorial | Table of Contents

Nanoparticles in Medicine
October 14, 2015 (Volume 115, Issue 19 pp. 10407-11190)
Editorial | Table of Contents

Enzymes

G-Protein Coupled Receptors
January 11, 2017 (Volume 117, Issue 1, pp. 1-246)
Editorial | Table of Contents

Protein Ensembles and Allostery
June 8, 2016 (Volume 116, Issue 11, pp. 6263-6742)
Editorial | Table of Contents
 13, pp. 8481-9520)
Editorial | Table of Contents

​
Enjoy reading!

Schrödinger, Inc  will be presenting its 5th European Life Science Bootcamp – a series of live webinars that will cover a wide range of popular topics, and will be fully interactive – each webinar will consist of 10 minutes of presentation, 20 minutes of software demonstration, followed by live Q&A with the presenter.

Schrödinger's 5th European Life Science Bootcamp will run from Monday, March 20th through Thursday, March 24th, covering the following topics:

• WaterMap for Lead Optimisation
• Introduction and Case Studies in Free Energy Perturbation for Lead Optimisation
• Becoming an Expert in PyMOL: Customization and Scripting
• Modelling Peptide Binding: From Structure to Properties
• Using Phase for Pharmacophore Modelling

Click here to learn more, and to register for any of the sessions. Note that each session will be recorded and all registrants will automatically receive a link to the session recording.

The recordings from previous European Life Science Bootcamps can be found here:

• 1st Life Science Bootcamp
• 2nd Life Science Bootcamp
• 3rd Life Science Bootcamp
• 4th Life Science Bootcamp

If you should be a sudoer in ubuntu but somehow the system is broken and you can no longer make administrative changes, follow the procedure below to re-enter the sudoers list.

$ sudo ls
[sudo] password for stephane:
stephane is not in the sudoers file. This incident will be reported.

1. During boot, press and hold the left Shift key, and you should see the GRUB menu.
   
2. Select the entry containing (recovery mode) and wait.
   
3. You should now be presented with a menu. Select:
   remount Remount / read/write and mount all other file systems
   
   
   

If this option doesn't appear or won't work, you can instead choose the root option and use the following command to mount the system partition:
mount -o remount /
or
mount -o rw,remount /

After applying this variation, adding a user to the admin (11.10 and ealrier) or sudo (12.04 and later) group is done like:
adduser username admin # 11.10 and earlier
adduser username sudo # 12.04 and later
​

Using mount

1. Get the Information
Sometimes, devices don't automount, in which case you should try to manually mount them. First, you must know what device you are dealing with and what filesystem it is formatted with. Most flash drives are FAT16 or FAT32 and most external hard disks are NTFS. Type the following: 
sudo fdisk -lFind your device in the list. It is probably something like /dev/sdb1. For more information about filesystems, see LinuxFilesystemsExplained. 


2. Create the Mount Point
Now we need to create a mount point for the device. Let's say we want to call it "external". You can call it whatever you want, but if you use spaces in the name it gets a little more complicated. Instead, use an underscore to separate words (like "my_external"). Create the mount point: 
sudo mkdir /media/external

3. Mount the Drive
We can now mount the drive. Let's say the device is /dev/sdb1, the filesystem is FAT16 or FAT32 (like it is for most USB flash drives), and we want to mount it at /media/external (having already created the mount point): 
sudo mount -t vfat /dev/sdb1 /media/external -o uid=1000,gid=1000,utf8,dmask=027,fmask=137The options following the "-o" give you ownership of the drive, and the masks allow for extra security for file system permissions. If you don't use those extra options you may not be able to read and write the drive with your regular username. 
Otherwise, if the device is formatted with NTFS, run: 
sudo mount -t ntfs-3g /dev/sdb1 /media/external
Note: You must have the ntfs-3g driver installed. See MountingWindowsPartitions for more information.

4. Unmounting the Drive
When you are finished with the device, don't forget to unmount the drive before disconnecting it. Assuming /dev/sdb1 is mounted at /media/external, you can either unmount using the device or the mount point: 
sudo umount /dev/sdb1or: 
sudo umount /media/externalYou cannot unmount from the desktop by right-clicking the icon if the drive was manually mounted. 

This information is taken from https://help.ubuntu.com/community/Mount/USB