|Molecular Modeling and Drug Design||
Novartis First-Generation Lung Cancer Drug Tweaked To Reduce Potential Side Effects
In the body, a compound’s electron-rich aniline group tends to change into a highly reactive quinone that can bind to nontarget proteins. Novartis’ first-generation inhibitor of the enzyme anaplastic lymphoma kinase (TAE684, left) had such an aniline group formed potentially harmful protein adducts in the body. To reduce side effects, chemists moved the position of the troublesome nitrogen to make the current version of the drug. For more information see:
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Alexis, Maria, Dimitra, Ioannis, Michalis, Danai, Panos, George, Aspa, Zoe
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